- Provided the growls for TV's The Incredible Hulk (1977).
- Served with the 11th Airborne.
- Was in two "Star Trek" series as diametrically-opposed characters: the Star Trek (1966) episode, The Way to Eden (1969), as the paradise-seeking hippie "Adam", and in the Star Trek: Deep Space Nine (1993) episode, Little Green Men (1995), as the no-nonsense "Gen. Denning" at Area 51 who interrogates the Ferengi Quark, Rom and Nog.
- Was friends with Hunter S. Thompson, and Bill Bixby.
- Roger Ebert often referred to him as "that character actor with a smile like Jaws".
- Appeared in 10 films directed by Jonathan Demme.
- He was once asked in real life for "McElroy's" autograph, the country and western front man for the Good Ol' Boys in the comedy The Blues Brothers (1980) ...and gave it.
- Appeared in four Russ Meyer movies: Cherry, Harry & Raquel! (1969) (in which he went full frontal), Beyond the Valley of the Dolls (1970) and The Seven Minutes (1971) (both of which he kept his clothes on), and Supervixens (1975) (in which he used a humongous rubber phallus or dildo as a "stand-in").
- Enjoyed painting with watercolors.
- Played in two Kentucky high school state basketball championships.
- Appeared on Dr. Phil (2002) with his wife to discuss his obsession with being famous.
- Worked as an "on the road" correspondent for the trucker magazine "Overdrive" in the early 1970s.
- Napier played a prison warden on at least 3 separate, unrelated occasions: Ernest Goes to Jail (1990); in a 1999 episode of Walker, Texas Ranger (1993) (Fight or Die (1999)); and in several episodes of The Simpsons (1989).
- On Men in Black: The Series (1997), Napier provided the voice of "Zed", a role originally played in the live-action films by Rip Torn, who co-starred with Napier in the 1989 low-budget action flick, Hit List (1989).
- The second of three children born to a tobacco farmer (Linus Pitts Napier; died 1991, aged 102), and a homemaker. Charles Napier was stationed in Germany for three years while in the Army, serving with the 11th Airborne. He later earned a bachelor's degree in art from Western Kentucky University in 1961 and worked as a substitute teacher after arriving in Los Angeles in the mid-1960s.
- He has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: The Blues Brothers (1980) and The Silence of the Lambs (1991).
- He made guest appearances on both Lois & Clark: The New Adventures of Superman (1993) and Superman: The Animated Series (1996).
- Napier starred in one of the first widely shown films to contain full frontal male nudity: Cherry, Harry & Raquel! (1969). It was such an event that "Variety", the Bible of Hollywood trade papers, contacted Napier's mother to find out her reaction to her son appearing in what was known in the exploitation industry as a "pickle shot.".
- He is survived by three offspring: son Charles Lewis "Chuck" Napier, Junior (B. June 23, 1964); son Hunter Charles Napier (B. May 10, 1988); and daughter Meghan Sara Lena Napier (B. June 11, 1991).
- He played a US Army officer who was involved in the Roswell UFO Incident in both Little Green Men (1995) and Summer of '47 (2000).
- His role in Walter Hill's The Streetfighter (1975) was cut from the final print.
- Was considered for the role of Sheriff Ed Landis in Jason Goes to Hell: The Final Friday (1993).
- Having a cameo in Austin Powers: The Spy Who Shagged Me (1999), there's a joke about Dr. Evil getting away in a rocket that looks like a woman's husband's one-eyed monster. Ironically, ten years later, he starred in a movie titled One-Eyed Monster (2008).
- He is interred at the Bakersfield National Cemetery in Bakersfield, California.
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