ELK1

ELK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DUX
Dynodwyr
Cyfenwau	ELK1, ETS transcription factor, ETS transcription factor ELK1
Dynodwyr allanol	OMIM: 311040 HomoloGene: 3832 GeneCards: ELK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • chromatin binding • GO:0001948, GO:0016582 protein binding • double-stranded DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • axon terminus • nucleoplasm • soma • dendrite • mitocondria • cnewyllyn cell Prosesau biolegol • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • response to light stimulus • cellular response to testosterone stimulus • response to fibroblast growth factor • positive regulation of neuron death • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • cellular response to gamma radiation • cellular response to lipid • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2002	n/a
Ensembl	ENSG00000126767	n/a
UniProt	P19419	n/a
RefSeq (mRNA)	NM_005229 NM_001114123 NM_001257168	n/a
RefSeq (protein)	NP_001107595 NP_001244097 NP_005220	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ELK1 yw ELK1 a elwir hefyd yn ELK1, ETS transcription factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xp11.23.^[2]

• "Silodosin inhibits prostate cancer cell growth via ELK1 inactivation and enhances the cytotoxic activity of gemcitabine. ". Prostate. 2016. PMID 26864615.
• "Downregulated protein expression of transcriptional activator ELK-1 in atrial myocardium of chronic AF patients. ". Int J Clin Exp Pathol. 2015. PMID 26617947.
• "ELK1 is up-regulated by androgen in bladder cancer cells and promotes tumor progression. ". Oncotarget. 2015. PMID 26342199.
• "Human pluripotent stem cells with distinct X inactivation status show molecular and cellular differences controlled by the X-Linked ELK-1 gene. ". Cell Rep. 2013. PMID 23871667.
• "Immunohistochemical study of pElk-1 expression in human breast cancer: association with breast cancer biologic profile and clinicopathologic features.". Breast. 2013. PMID 23127278.