Azidomorfin

Azidomorfin
(IUPAC) ime
	6-β-azido- 4,5-α-epoksi- 17-metil- morfinan- 3-ol
Klinički podaci
Identifikatori
CAS broj	22952-87-0
ATC kod	nije dodeljen
PubChem	5488848
ChemSpider	4590009
Hemijski podaci
Formula	C17H20N4O2
Mol. masa	312,366 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C17H20N4O2/c1-21-7-6-17-10-3-4-11(19-20-18)16(17)23-15-13(22)5-2-9(14(15)17)8-12(10)21/h2,5,10-12,16,22H,3-4,6-8H2,1H3/t10-,11+,12+,16-,17-/m0/s1 ; Key: KZOKOEQTKWBKOK-XHQKLZHNSA-N
Sinonimi	Azidomorphine
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Azidomorfin^[4] je opijatni analog koji je izveden iz morfina, tako što je 7,8 dvostruka veza bila zasićena i 6-hidroksilna grupa zamenjena azidnom grupom.^[5]

Azidomorfin se vezuje sa visokim afinitetom za mi opioidni receptor,^[6] i oko 40x je potentniji od morfina in vivo. On ima slično dejsto sa morfinom uključujući analgeziju, sedaciju i respiratornu depresiju. Međutim utvrđeno je da ima nešto manju sklonost izazivanja zavisnosti.^[7]^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ US patent 3880862, Šablon:Cite patent/authors, "6β-Azido-17-cycloalkylmethyl-4,5α-epoxymorphinan-3-ols", issued 29. 4. 1975., assigned to Warner-Lambert
↑ Knoll, J.; Fürst, S.; Kelemen, K. (1973). „The pharmacology of azidomorphine and azidocodeine”. Journal of Pharmacy and Pharmacology 25 (12): 929–939. PMID 4150295.
↑ Horváth, K.; Wollemann, M. (1986). „Azidomorphine is an agonist of high-affinity opioid receptor binding sites”. Neurochemical Research 11 (11): 1565–1569. PMID 2825053.
↑ Knoll, J. (1979). „Azidomorphines: A new family of potent analgesics with low dependence capacity”. Progress in Neuropsychopharmacology 3 (1–3): 95–108. PMID 45567.
↑ Hill, R. C.; Roemer, D.; Buescher, H. (1977). „Investigations of the analgesic and morphine-like properties of azidomorphine”. Journal of Pharmacology and Experimental Therapeutics 201 (3): 580–586. PMID 405472.

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] US patent 3880862, Šablon:Cite patent/authors, "6β-Azido-17-cycloalkylmethyl-4,5α-epoxymorphinan-3-ols", issued 29. 4. 1975., assigned to Warner-Lambert

[5] Knoll, J.; Fürst, S.; Kelemen, K. (1973). „The pharmacology of azidomorphine and azidocodeine”. Journal of Pharmacy and Pharmacology 25 (12): 929–939. PMID 4150295.

[6] Horváth, K.; Wollemann, M. (1986). „Azidomorphine is an agonist of high-affinity opioid receptor binding sites”. Neurochemical Research 11 (11): 1565–1569. PMID 2825053.

[7] Knoll, J. (1979). „Azidomorphines: A new family of potent analgesics with low dependence capacity”. Progress in Neuropsychopharmacology 3 (1–3): 95–108. PMID 45567.

[8] Hill, R. C.; Roemer, D.; Buescher, H. (1977). „Investigations of the analgesic and morphine-like properties of azidomorphine”. Journal of Pharmacology and Experimental Therapeutics 201 (3): 580–586. PMID 405472.

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