streptomycin (Q192717)

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chemical compound
  • SM
  • STREPTOMYCIN
  • [2-Deoxy-2-(dimethylamino)-alpha-L-glucopyranosyl]-(1->2)-[5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl]-(1->4)-{n',n'''-[(1,3,5/2,4,6)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine}
  • Kantrex
  • 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside
  • streomycin
  • 2,4-diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside
  • Streptomycin
  • Estreptomicina
  • Streptomyzin
  • Streptomicina
edit
Language Label Description Also known as
default for all languages
No label defined
    English
    streptomycin
    chemical compound
    • SM
    • STREPTOMYCIN
    • [2-Deoxy-2-(dimethylamino)-alpha-L-glucopyranosyl]-(1->2)-[5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl]-(1->4)-{n',n'''-[(1,3,5/2,4,6)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine}
    • Kantrex
    • 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside
    • streomycin
    • 2,4-diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside
    • Streptomycin
    • Estreptomicina
    • Streptomyzin
    • Streptomicina

    Statements

    mass
    581.266 dalton
    1 reference
    stated in
    PubChem
    PubChem CID
    19649
    language of work or name
    English
    title
    streptomycin (English)
    retrieved
    19 October 2016
    chemical formula
    C₂₁H₃₉N₇O₁₂
    1 reference
    stated in
    PubChem
    PubChem CID
    19649
    language of work or name
    English
    title
    streptomycin (English)
    retrieved
    19 October 2016
    canonical SMILES
    CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O
    1 reference
    stated in
    PubChem
    PubChem CID
    19649
    language of work or name
    English
    title
    streptomycin (English)
    retrieved
    19 October 2016
    isomeric SMILES
    CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]3NC(N)=N)O[C@@H](C)[C@]2(O)C=O
    1 reference
    stated in
    Global Substance Registration System
    UNII
    Y45QSO73OB
    retrieved
    14 February 2018
    found in taxon
    Streptomyces griseus
    47 references
    stated in
    Effect of sclerin on production of the aminoglycoside antibiotics accompanied by salvage function in Streptomyces.
    stated in
    BIOSYNTHESIS OF STREPTOMYCINS
    stated in
    Streptomycin biosynthesis inStreptomyces griseusII. Adjacent genomic location of biosynthetic genes and one of two streptomycin resistance genes
    stated in
    Streptomycin biosynthesis inStreptomyces griseusI. Characterization of streptomycin-idiotrophic mutants
    stated in
    Streptomycin-induced expression in Bacillus subtilis of YtnP, a lactonase-homologous protein that inhibits development and streptomycin production in Streptomyces griseus
    stated in
    Streptomyces antibiotics; structure of streptomycin
    stated in
    Strain- and species-specific distribution of the streptomycin gene cluster and kan-related sequences in Streptomyces griseus.
    stated in
    tmRNA of Streptomyces collinus and Streptomyces griseus during the growth and in the presence of antibiotics
    stated in
    Gene cluster for streptomycin biosynthesis in Streptomyces griseus: nucleotide sequence of three genes and analysis of transcriptional activity
    stated in
    Expression analysis of the ssgA gene product, associated with sporulation and cell division in Streptomyces griseus
    stated in
    Detection and properties of A-factor-binding protein from Streptomyces griseus
    stated in
    Identification and gene disruption of small noncoding RNAs in Streptomyces griseus.
    stated in
    The A-factor regulatory cascade and cAMP in the regulation of physiological and morphological development in Streptomyces griseus
    stated in
    A-factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus
    stated in
    The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus : identification of a target gene of the A-factor receptor
    stated in
    Nucleotide sequence of the streptomycinphosphotransferase and amidinotransferase genes from Streptomyces griseus
    stated in
    Biosynthesis of streptomycin enzymic oxidation of dihydrostreptomycin (6-phosphate) to streptomycin (6-phosphate) with a particulate fraction of Streptomyces griseus
    stated in
    STREPTOMYCIN FORMATION BY INTACT MYCELIUM OF STREPTOMYCES GRISEUS
    stated in
    Activation of secondary metabolite-biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus
    stated in
    Cloning and characterization of a gene involved in aerial mycelium formation in Streptomyces griseus.
    stated in
    Identification of an A-factor-dependent promoter in the streptomycin biosynthetic gene cluster of Streptomyces griseus.
    stated in
    Possible involvement of cAMP in aerial mycelium formation and secondary metabolism in Streptomyces griseus
    stated in
    Ribosomal ribonucleic acids from Streptomyces griseus.
    stated in
    Dependence on reporter gene of apparent activity in gene fusions of a Streptomyces griseus streptomycin biosynthesis promoter
    stated in
    Isolation and characterization of pock-forming plasmids for Streptomyces griseus from soil actinomycetes
    stated in
    Mutants blocked in streptomycin production in Streptomyces griseus - the role of A-factor
    stated in
    Gene cluster for streptomycin biosynthesis in Streptomyces griseus: analysis of a central region including the major resistance gene
    stated in
    Genetics of streptomycin production in Streptomyces griseus: molecular structure and putative function of genes strELMB2N
    stated in
    Physiological factors affecting streptomycin production byStreptomyces griseusATCC 12475 in batch and continuous culture
    stated in
    Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350
    stated in
    An A-factor-dependent extracytoplasmic function sigma factor (sigma(AdsA)) that is essential for morphological development in Streptomyces griseus
    stated in
    Sporulation of Streptomyces griseus in submerged culture.
    stated in
    Intracellular cyclic adenosine 3′,5′-monophosphate levels and streptomycin production in cultures of Streptomyces griseus
    stated in
    Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: significance of the stringent response (ppGpp) and GTP content in relation to A factor
    stated in
    Genetic analysis of A-factor synthesis in Streptomyces coelicolor A3(2) and Streptomyces griseus
    stated in
    Properties of C-terminal truncated derivatives of the activator, StrR, of the streptomycin biosynthesis in Streptomyces griseus
    stated in
    An alternative sigma factor governs the principal sigma factor in Streptomyces griseus.
    stated in
    Strict regulation of morphological differentiation and secondary metabolism by a positive feedback loop between two global regulators AdpA and BldA in Streptomyces griseus
    stated in
    Crystal structure of L-arginine:inosamine-phosphate amidinotransferase StrB1 from Streptomyces griseus: an enzyme involved in streptomycin biosynthesis
    stated in
    Cloning and characterization of the A-factor receptor gene from Streptomyces griseus
    stated in
    Biosynthesis of streptomycin. Purification and properties of a dTDP-L-dihydrostreptose: streptidine-6-phosphate dihydrostreptosyltransferase from Streptomyces griseus
    stated in
    Myo-inositol-1-phosphate synthase from streptomyces griseus (Studies on the biosynthesis of cyclitols, XXXVIII1)
    stated in
    The A-factor-binding protein of Streptomyces griseus negatively controls streptomycin production and sporulation
    stated in
    Nucleotide sequence of a principal sigma factor gene (hrdB) of Streptomyces griseus
    stated in
    Intracellular levels of guanosine 5′-diphosphate 3′-diphosphate (ppGpp) and guanosine 5′-triphosphate 3′-diphosphate (pppGpp) in cultures of Streptomyces griseus producing streptomycin
    stated in
    Cross-interaction of anti-σH factor RshA with BldG, an anti-sigma factor antagonist in Streptomyces griseus
    stated in
    Resistance to streptomycin in a producing strain of Streptomyces griseus
    significant drug interaction
    Commons category
    Streptomycin
    0 references

    Identifiers

    NDL Authority ID
    00571777
    0 references
    Reaxys registry number
    74498
    1 reference
    stated in
    ChEBI
    ChEBI ID
    17076
    language of work or name
    English
    title
    streptomycin (English)
    retrieved
    19 October 2016
    HSDB ID
    1768
    1 reference
    stated in
    Hazardous Substances Data Bank
    HSDB ID
    1768
    publication date
    28 October 2019
    title
    Streptomycin (English)
    retrieved
    10 May 2021
    ATC code
    J01GA
    0 references
    MeSH descriptor ID
    D013307
    subject named as
    Streptomycin
    0 references
    KEGG ID
    D08531
    1 reference
    stated in
    ChEBI
    ChEBI ID
    17076
    language of work or name
    English
    title
    streptomycin (English)
    retrieved
    19 October 2016
    C00413
    0 references
    PDB ligand ID
    SRY
    0 references
    FactGrid item ID
    Q949062
    1 reference
    stated in
    FactGrid
    retrieved
    10 December 2024
    Lex ID
    streptomycin
    0 references
    NALT ID
    7873
    0 references
    PDB structure ID
    WordNet 3.1 Synset ID
    04343518-n
    1 reference
    stated in
    GF WordNet
     
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