crizotinib (Q5186964)

3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

Crizotinib (English)

19 October 2016

1 reference

based on heuristic

inferred from InChIKey

chemical formula

C₂₁H₂₂Cl₂FN₅O

1 reference

Crizotinib (English)

19 November 2016

CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

1 reference

Crizotinib (English)

19 November 2016

C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

1 reference

World Health Organisation international non-proprietary name

Crizotinib (English)

19 November 2016

1 reference

14 February 2018

crizotinib (English)

1 reference

crizotinib (English)

medical condition treated

19 October 2016

inflammatory myofibroblastic tumour

1 reference

non-small-cell lung carcinoma

2 October 2018

1 reference

2 October 2018

bronchus carcinoma

1 reference

neuroblastoma, susceptibility to

2 October 2018

1 reference

significant drug interaction

2 October 2018

amiodarone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ondansetron

1 reference

A reference set of clinically relevant adverse drug-drug interactions

arsenic trioxide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

disopyramide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sunitinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

toremifene

1 reference

A reference set of clinically relevant adverse drug-drug interactions

dasatinib monohydrate

1 reference

A reference set of clinically relevant adverse drug-drug interactions

lapatinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sorafenib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

anagrelide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

moxifloxacin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

dronedarone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

vandetanib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

droperidol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pimozide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

haloperidol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

chlorpromazine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-citalopram

1 reference

A reference set of clinically relevant adverse drug-drug interactions

zuclopenthixol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pasireotide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-hydroxyzine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-sulpiride

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-methadone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pazopanib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sotalol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nilotinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

voriconazole

1 reference

A reference set of clinically relevant adverse drug-drug interactions

erythromycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

clarithromycin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

quinine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-metoprolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nadolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

atenolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nebivolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

acebutolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

betaxolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

digoxin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

bisoprolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pindolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

carvedilol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

propranolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

labetalol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

clonidine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

celiprolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

esmolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

levobunolol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

diltiazem

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sotalol

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pentamidine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

mefloquine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fingolimod

1 reference

A reference set of clinically relevant adverse drug-drug interactions

domperidone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

bosutinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ceritinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-methadone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

verapamil

1 reference

A reference set of clinically relevant adverse drug-drug interactions

amiodarone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

alfentanil

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sufentanil

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fingolimod

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pasireotide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ivabradine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

donepezil

1 reference

probably

A reference set of clinically relevant adverse drug-drug interactions

galantamine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ivabradine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ergotamine

ergotism

1 reference

A reference set of clinically relevant adverse drug-drug interactions

arsenic trioxide

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sunitinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

dasatinib monohydrate

1 reference

A reference set of clinically relevant adverse drug-drug interactions

sorafenib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

paclitaxel

1 reference

A reference set of clinically relevant adverse drug-drug interactions

nilotinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pentamidine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pazopanib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

bosutinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

dabrafenib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ibrutinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ceritinib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

idelalisib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

amiodarone

1 reference

A reference set of clinically relevant adverse drug-drug interactions

dabrafenib

1 reference

A reference set of clinically relevant adverse drug-drug interactions

galantamine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

quetiapine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

(RS)-sulpiride

1 reference

A reference set of clinically relevant adverse drug-drug interactions

alfentanil

central respiratory depression

1 reference

A reference set of clinically relevant adverse drug-drug interactions

donepezil

1 reference

probably

A reference set of clinically relevant adverse drug-drug interactions

donepezil

1 reference

probably

A reference set of clinically relevant adverse drug-drug interactions

sufentanil

central respiratory depression

1 reference

A reference set of clinically relevant adverse drug-drug interactions

itraconazole

1 reference

established

A reference set of clinically relevant adverse drug-drug interactions

ritonavir

1 reference

A reference set of clinically relevant adverse drug-drug interactions

ketoconazole

1 reference

established

A reference set of clinically relevant adverse drug-drug interactions

ivabradine

1 reference

A reference set of clinically relevant adverse drug-drug interactions

fosphenytoin

1 reference

A reference set of clinically relevant adverse drug-drug interactions

tacrolimus

1 reference

A reference set of clinically relevant adverse drug-drug interactions

pregnancy category

Australian pregnancy category D

1 reference

imported from Wikimedia project

English Wikipedia

US pregnancy category D

1 reference

imported from Wikimedia project

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category C

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Crizotinib

last update

30 October 2017

subject has role

xenobiotic-transporting ATPase inhibitor

1 reference

5 March 2018

protein kinase inhibitors

1 reference

InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1

Medical Subject Headings

15 March 2018

Crizotinib

0 references

Identifiers

InChI

1 reference

Crizotinib (English)

19 November 2016

2 references

Crizotinib (English)

19 November 2016

ChEBI release 2020-09-01

CAS Registry Number

877399-52-5

2 references

crizotinib (English)

19 November 2016

https://commonchemistry.cas.org/detail?cas_rn=877399-52-5

8 April 2021

1 reference

Crizotinib (English)

19 October 2016

2 references

Crizotinib (English)

19 November 2016

Reaxys registry number

12133926

1 reference

crizotinib (English)

19 October 2016

mapping relation type

2 references

CRIZOTINIB (English)

19 November 2016

International Chemical Identifier

InChI

InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1

1 reference

CRIZOTINIB (English)

19 November 2016

2 references

inferred from InChIKey

splash10-0udi-1693800000-fc52c38f3359a378554a

1 reference

0 references

DSSTox substance ID

DTXSID701009329

1 reference

DSSTOX compound identifier

0 references

0 references

0 references

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.166.440

27 December 2018

ECHA Substance Infocard ID

2-Pyridinamine,3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl] (English)

quotation

CAS no.: 877399-52-5 (English)

100.166.440

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.166.440

27 December 2018

2-Pyridinamine,3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl] (English)

quotation

CAS no.: 877399-52-5 (English)

1 reference

Guide to Pharmacology Ligand ID

Crizotinib (English)

publication date

17 November 2015

4903

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4903

crizotinib (English)

19 November 2016

Crizotinib

0 references

0 references

0 references

1 reference

crizotinib (English)

19 November 2016

1 reference

2 references

crizotinib (English)

19 November 2016

MedlinePlus drug identifier

a612018

0 references

PatientsLikeMe treatment ID

0 references

1 reference

crizotinib (English)

19 November 2016

0 references

1 reference

1 reference

electronic Essential Medicines List medicine ID

crizotinib (English)

19 October 2016

0 references

0 references

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

4C9W (English)

19 October 2016

1 reference

2WGJ (English)

19 October 2016

1 reference

3ZBF (English)

19 October 2016

1 reference

5AAA (English)

19 October 2016

1 reference

5AAC (English)

19 October 2016

1 reference

5AAB (English)

19 October 2016

1 reference

2XP2 (English)

19 October 2016

1 reference

4ANS (English)

19 October 2016

1 reference

4ANQ (English)

19 October 2016

1 reference

2YFX (English)

19 October 2016

1 reference